ArticleFrontiers in cellular and infection microbiology2026
High-salt diet promotes atopic dermatitis by partially enhancing intestinal SGK1/ENaC signaling and destroying gut
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Systemic type 1 interferon (IFN1), which is regulated by intestinal homeostasis, shows potential in inhibiting the immunoglobulin E (IgE) production and Th2 response Methods: MC903 was applied topically to establish AD in wild-type C57BL/6 mice; in mice with IFN1 receptor-1 ( Results: HSD significantly promoted AD accompanied by higher levels of serum IgE, IL-4/IL-13, ileum SGK1, phosphorylated SGK1, βENaC and γENaC, and skin sodium, but lower levels of serum IFN1, ileum ZO-1, gut Conclusion: HSD promotes AD by partially impairing the systemic IFN1 production that is orchestrated by STING signaling in DCs by reducing the gut
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