ArticleCancer heterogeneity and plasticity2026
Keratin 5 expression defines a niche-supported hierarchy in tubo-ovarian cancer.
Article in Cancer heterogeneity and plasticity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tubo-ovarian high-grade serous carcinoma (HGSC) is characterized by extreme cellular heterogeneity. A tumorigenic subset of cancer-propagating cells (CPC) with stem-like properties coexists with a large population of non-cancer-propagating cells (non-CPC), but the functional interplay between these two cell types remains poorly understood. In this issue, Bidarimath et al. identify keratin 5 (KRT5) as a marker of CPC in HGSC and propose a niche model in which osteopontin (OPN) sustains KRT5-positive CPC through interactions with KRT5-negative, non-tumorigenic cells. By combining in vitro, in vivo, and patient-derived data, the study links a supportive tumor microenvironment to the maintenance of a phenotypically defined CPC population.
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