SynthesisFrontiers in medicine2026
The value of chest CT in the differential diagnosis of benign and malignant pulmonary nodules: a meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
Background: This study was conducted to systematically evaluate the diagnostic value of computed tomography (CT) in differentiating benign and malignant pulmonary nodules through a meta-analysis, thereby providing a solid evidence-based foundation for clinical diagnosis and treatment decisions. Methods: We searched the PubMed, Web of Science, Embase, Medline, China National Knowledge Infrastructure (CNKI), and Cochrane Library databases for relevant studies published up to December 2025 and performed a meta-analysis using Review Manager v.5.4. Results: A total of 28 retrospective analyses and 19 prospective studies were included, comprising 4,705 patients with pulmonary nodules. The pooled sensitivity of CT was 0.90 (95% confidence interval [CI]: 0.89-0.91; Conclusion: These findings indicate that CT has a high diagnostic value in differentiating benign from malignant pulmonary nodules and is an important method for evaluating pulmonary nodules in clinical practice. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261277036, Identifier: CRD420261277036.
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