ArticleFrontiers in cellular neuroscience2026
Acute hyperexcitability differentially affects hippocampal neurogenesis features and spatial memory.
Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Epileptic seizures induce aberrant adult hippocampal neurogenesis (AHN), yet how varying seizure intensities affect this process and associated memory functions remains unclear. Methods: Here we administered systemically a low (5 mg/kg) or a high (25 mg/kg) dose of kainic acid (KA) to induce acute hyperexcitability of differing severity in mice of both sexes (6 to 8 weeks-old) genetically labeled for Ascl1, which allowed to follow progenitor cells and their progeny in the dentate gyrus (DG). We recorded EEG, assessed spatial and contextual fear memory, and analyzed adult-born granule cells (abGCs) 32 days post-treatment. Results: High-dose KA produced more severe and prolonged seizures, increased mature abGCs with altered laminar positioning, and elevated dendritic spine density, whereas low-dose KA induced presynaptic bouton enlargement. Both doses impaired spatial location recognition but spared contextual fear memory. Discussion: These findings reveal that acute seizure severity differentially modulates morphological and synaptic features of abGCs and selectively disrupts hippocampal-dependent spatial memory, indicating that hyperexcitability exerts qualitative effects on neurogenesis and cognitive function.
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