Evidence map›Paper›PMID 42311776›Full record

ArticleClinical case reports2026

Exudative Retinal Detachments: A Rare Adverse Effect of Topiramate.

Sarah Aljefri, Meshal Alzakari, Bailasan Milibari, Doaa Milibari

Abstract read
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah AljefriDepartment of Ophthalmology, College of Medicine Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia.ORCID https://orcid.org/0000-0001-8975-8392
Meshal AlzakariCollege of Medicine Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia.ORCID https://orcid.org/0000-0002-4530-4708
Bailasan MilibariFaculty of Medicine Umm Al-Qura University Makkah Saudi Arabia.ORCID https://orcid.org/0009-0003-7303-8712
Doaa MilibariKing Abdullah Medical City (KAMC) Eye Center Makkah Saudi Arabia.ORCID https://orcid.org/0000-0001-7424-3409

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Topiramate-induced multifocal exudative retinal detachment is a rare but potentially vision-threatening adverse effect. We report a 59-year-old woman with idiopathic intracranial hypertension who developed painless bilateral blurry vision and color desaturation 8 days after initiation of topiramate 25 mg twice daily. Fundus examination and spectral-domain optical coherence tomography demonstrated bilateral multifocal exudative retinal detachment with subretinal fluid. Extensive infectious and inflammatory investigations were unremarkable. Topiramate was discontinued, resulting in complete anatomical resolution of subretinal fluid and improvement of visual acuity to 20/30 in both eyes over 3 months of follow-up. This case highlights the importance of recognizing this uncommon ocular complication and the potential for complete recovery following prompt drug cessation.

Indexed as

exudative retinal detachmentidiopathic intracranial hypertensionocular toxicitytopiramate

Identifiers

PMID42311776
PMCPMC13269651

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.