ReviewFrontiers in cardiovascular medicine2026
Impact of hypertension history and blood pressure parameters on cognitive impairment in patients with atrial fibrillation: a systematic review and meta-analysis.
Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cognitive impairment manifests as a gradual decline in the ability to perform daily activities. This study evaluates the impact of history of hypertension and blood pressure parameters on cognitive impairment in patients with atrial fibrillation (AF). Methods: We systematically searched eight databases (CNKI, Wanfang, VIP, CBM, PubMed, Embase, Cochrane Library, Web of Science) from inception to September 7, 2025, for observational studies examining associations between hypertension history, blood pressure parameters, and cognitive impairment in AF patients. Study quality was assessed using NOS (cohort/case-control) and AHRQ (cross-sectional) tools. Meta-analyses were performed separately for odds ratios (OR) and hazard ratios (HR) using RevMan 5.4. Heterogeneity was evaluated with I Results: A total of 20 studies involving 998,622 AF patients were included. We identified six potential risk factors for cognitive impairment in patients with atrial fibrillation from these 20 studies, three of which (history of hypertension, systolic blood pressure, diastolic blood pressure) were reported in sufficient studies to be included in a meta-analysis. Subgroup meta - analysis of OR showed that history of hypertension is associated with an increased risk of cognitive impairment in patients with atrial fibrillation (OR: 2.22, 95% CI: 2.15-2.30, Conclusion: History of hypertension and high-normal blood pressure levels are significantly associated with cognitive impairment in patients with AF. Identifying and intervening in these modifiable risk factors is crucial for prevention and treatment. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251186104, PROSPERO CRD420251186104.
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