Evidence map›Paper›PMID 42311760›Full record

ReviewFrontiers in genetics2026

The effect of human-specific genetic variants on neuronal spinogenesis.

Nicolás Matías Rosas, Anna Szombathy, Kinga Szigeti

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicolás Matías RosasDepartment of Neurology, State University of New York at Buffalo, Buffalo, NY, United States.
Anna SzombathyDepartment of Neurology, State University of New York at Buffalo, Buffalo, NY, United States.
Kinga SzigetiDepartment of Neurology, State University of New York at Buffalo, Buffalo, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fundamental morphological and functional differences between the brains of animal models and humans are at least partially related to human-specific genes and genetic variants. As one of the structural underpinnings of brain function is the dendritic spine, we systematically queried a curated list of human-specific genes and genetic variants. We found that with the current knowledge base, 4.3% are linked to the dendritic spine. Functionally these genes converge on the cytoskeleton, Ca

Indexed as

actin cytoskeletondendritic spinehuman brainhuman-specific genesneuropsychiatric disease

Identifiers

PMID42311760
PMCPMC13271839

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.