ArticleFrontiers in toxicology2026
Case Report: Ultra-early tangential excision combined with negative pressure wound therapy as a novel surgical detoxification strategy for severe hydrofluoric acid burns complicated by intractable hypocalcemia.
Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Severe hydrofluoric acid (HF) burns are life-threatening due to the rapid systemic absorption of fluoride ions, which precipitate profound hypocalcemia and fatal arrhythmias. Traditional conservative neutralization therapies often fail to halt the continuous absorption of toxins from deep necrotic tissues in high-concentration exposures. Case Presentation: We report a 40-year-old male presenting with severe HF burns (20% total body surface area) following exposure to 40% HF. The patient rapidly developed intractable hypocalcemia (Ca Conclusion: Proactive surgical source control through extremely early tangential excision, combined with NPWT, serves as a novel surgical detoxification strategy that effectively severs the continuous systemic absorption of fluoride. This strategy, validated by dynamic urinary fluoride monitoring, significantly improves survival in severe HF burns and warrants broader clinical adoption.
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