Evidence map›Paper›PMID 42311702›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Prevalence of Lewy body pathology and phenotypic associations in patients with mild cognitive impairment: Evidence from the Interceptor study.

Simone Baiardi, Serena Caldera, Sabina Capellari, Franco Magliocchetti, Angela Mammana, Corrado Zenesini, Stefano Cappa, Naike Caraglia, Maria Cotelli, Camillo Marra and 9 more

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In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Simone BaiardiDepartment of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy.
Serena CalderaIRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy.
Sabina CapellariDepartment of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy.
Franco MagliocchettiIRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy.
Angela MammanaIRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy.
Corrado ZenesiniIRCCS Istituto delle Scienze Neurologiche di Bologna Bologna Italy.
Stefano CappaUniversity Institute of Advanced Studies IUSS Pavia Italy.
Naike CaragliaMemory Clinic, Fondazione Policlinico Universitario "A. Gemelli" IRCCS Rome Italy.
Maria CotelliIRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy.
Camillo MarraMemory Clinic, Fondazione Policlinico Universitario "A. Gemelli" IRCCS Rome Italy.
Francesca MiragliaDepartment of Theoretical and Applied Sciences eCampus University Novedrate Italy.
Daniela PeraniVita-Salute San Raffaele University Milan Italy.
Alberto RedolfiIRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy.
Patrizia SpadinAssociazione italiana Malattia di Alzheimer, AIMA Milan Italy.
Fabrizio TagliaviniFondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy.
Nicola VanacoreNational Center for Disease Prevention and Health Promotion National Institute of Health Rome Italy.
Fabrizio VecchioDepartment of Theoretical and Applied Sciences eCampus University Novedrate Italy.
Paolo Maria RossiniDepartment of Neuroscience and Neurorehabilitation IRCCS San Raffaele Roma Rome Italy.
Piero ParchiDepartment of Biomedical and Neuromotor Sciences University of Bologna Bologna Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionClinical effects and prevalence of Lewy body (LB) pathology in patients with mild cognitive impairment (MCI) remain poorly understood.

methodsWe assessed LB pathology in 339 patients with MCI from the Italian multicenter Interceptor cohort using the cerebrospinal fluid α-synuclein seed amplification assay. Baseline assessment was followed by serial cognitive evaluations over 3 years.

resultsLB+ participants ( DISCUSSION: In a multicenter MCI cohort, LB pathology was associated with older age and an increased frequency of motor/psychiatric symptoms. Larger studies are needed to clarify the independent contribution of AD and LB pathologies to the MCI phenotype and clinical progression.

Indexed as

alpha‐synucleinAlzheimer's diseasedementia with Lewy bodiesreal‐time quaking‐induced conversion assay

Identifiers

PMID42311702
PMCPMC13269012

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