Evidence map›Paper›PMID 42311694›Full record

ArticleFrontiers in immunology2026

Development of a GMMA-based candidate vaccine against invasive nontyphoidal

Francesco Citiulo, Oliver Koeberling, Omar Rossi, Emilia Cappelletti, Carlo Giannelli, Maria Grazia Aruta, Daniele De Simone, Federico Pippi, Xhenti Ferhati, Antonia De Felice and 10 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Francesco CitiuloGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Oliver KoeberlingGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Omar RossiGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Emilia CappellettiGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Carlo GiannelliGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Maria Grazia ArutaGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Daniele De SimoneGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Federico PippiGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Xhenti FerhatiGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Antonia De FeliceGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Alessandra AcquavivaGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Angela DanieleGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Filomena De LucaGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Giulia IannelloGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Claudia G VitaliGSK Vaccines, Siena, Italy.
Francesca NecchiGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Laura B MartinGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Francesco Berlanda ScorzaGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Anna Maria ColucciGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.
Rocío CanalsGSK Vaccines Institute for Global Health S.r.l. (GVGH), Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Invasive nontyphoidal Methods: This work describes the pre-clinical development of a Generalized Modules for Membrane Antigens (GMMA)-based bivalent vaccine candidate against iNTS disease, known as iNTS-GMMA. Results: The iNTS-GMMA vaccine candidate induced in mice and rabbits high levels of IgG anti- Conclusions: These data supported clinical evaluation of this urgently needed vaccine against iNTS disease in sSA.

Indexed as

Antigens, BacterialSalmonella enteritidisSalmonella InfectionsSalmonella typhimuriumSalmonella VaccinesAnimalsAntibodies, BacterialFemaleHumansMiceRabbitsVaccine DevelopmentAntibodies, BacterialAntigens, BacterialSalmonella VaccinesGMMAinvasive nontyphoidal Salmonella (iNTS) diseaseOMVSalmonellavaccine

Identifiers

PMID42311694
PMCPMC13270084

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.