ReviewFrontiers in immunology2026
Exosomes in organ transplantation: roles in immunomodulation, ferroptosis and mitophagy.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
8 authors.
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Abstract
Exosomes are extracellular vesicles (EVs) with a lipid bilayer structure, ranging from 30 to 150 nm in diameter, that are secreted by cells. As key carriers of biological information, they play pivotal roles in diverse physiological and pathological processes, such as immune response, apoptosis, angiogenesis, and inflammation. Advancing research has revealed that exosomes transport immunomodulatory cargo relevant to transplantation, demonstrating their capacity to directly modulate immune rejection and tolerance, beyond merely serving as biomarkers for assessing graft function and acceptance. Consequently, exosomes present significant therapeutic potential in transplant immunology. Furthermore, ferroptosis and mitophagy, two burgeoning fields of research, are increasingly recognized to interact closely with exosomes and participate in coordinated pathophysiological processes. This review aims to summarize the characteristics of exosomes and elaborate on their roles, alongside ferroptosis and mitophagy, in organ transplantation, with a focus on their collective therapeutic implications.
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