ArticleOpen forum infectious diseases2026
Placental Pathogens Associated With Adverse Maternal and Neonatal Outcomes.
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Background: Bacterial infection at the maternal-fetal interface contributes to adverse pregnancy outcomes, including preterm birth, chorioamnionitis, and sepsis. Despite evolving obstetric practices that may influence microbial patterns, recommended clinical algorithms for prophylaxis and treatment rely on outdated data. Furthermore, the pathogenic organisms associated with adverse outcomes remain incompletely characterized. Methods: We conducted a retrospective study of placental cultures from a high-risk obstetric cohort from a single hospital system between 2014 and 2019 (n = 714). Placental cultures were obtained from deliveries at high risk for infection: (eg, preterm birth or suspected chorioamnionitis). Placental cultures were stratified into pathogenic and nonpathogenic. Associated clinical outcomes, histopathology, and antimicrobial susceptibility patterns were compared. Results: Pathogenic organisms were identified in 69% of cultures (492 of 714). Group B Conclusions: Bacterial pathogens isolated from the placenta in high-risk pregnancies are associated with perinatal morbidity. Group B
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