Evidence map›Paper›PMID 42311648›Full record

ArticleOpen forum infectious diseases2026

Primary Cryptococcal Cellulitis With High Antigenemia in an Immunocompromised Host: A Case Report and Laboratory Investigation of the Causative

Hannah M Hamad, Charles A Specht, Diana Carlson, Vikas Yadav, Rajendra Upadhya, Joseph Heitman, Colleen Gabel, Patrick O'Donnell, Farha A P Karlath, Fozia Qamar and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hannah M HamadDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0009-0002-0677-1415
Charles A SpechtDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5749-3112
Diana CarlsonDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0009-0009-5268-0646
Vikas YadavDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0003-2650-9035
Rajendra UpadhyaDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-7613-2518
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-6369-5995
Colleen GabelDepartment of Dermatology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Patrick O'DonnellDepartment of Dermatology and Department of Pathology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6919-4451
Farha A P KarlathDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0002-4245-3919
Fozia QamarDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Michael NewsteinDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Stuart M LevitzDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3799-3064

Funding

A subunit Cryptococcus vaccineR01AI172154 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Stuart Michael Levitz · 2022 to 2026
$3.1M
NIAID NIH HHS R01 AI172154
6 · The paper itself

Abstract

Cutaneous cryptococcosis, although rare, may arise as primary inoculation or as part of disseminated cryptococcal infection, particularly in immunocompromised hosts. We present the case of an 80-year-old man with type 2 diabetes mellitus receiving corticosteroid therapy for cryptogenic organizing pneumonia who developed cryptococcal cellulitis with a markedly elevated serum cryptococcal antigen (CrAg) titer but no discernible central nervous system (CNS) involvement. As high serum CrAg titers are strongly associated with CNS disease, we compared the patient isolate (designated MA-1) with the

Indexed as

aneuploidycellulitisCryptococcus neoformansfungal genomeimmunocompromised hostmouse virulence

Identifiers

PMID42311648
PMCPMC13270244

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.