Trial reportOpen forum infectious diseases2026
Pharmacokinetics of Oral Amoxicillin for the Treatment of Syphilis in Pregnancy.
Trial report in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Expanding treatment options for syphilis during pregnancy: a review of alternatives to penicillin.Frontiers in global women's health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This open-label study compared single-dose oral amoxicillin pharmacokinetics during pregnancy and postpartum relative to the established in vivo minimum inhibitory concentration (MIC) for Methods: Pregnant women in good health at 24-34 weeks gestational age prescribed amoxicillin for preterm premature rupture of membranes were eligible. A 500-mg oral dose was administered at enrollment and 6 weeks postpartum. Blood was collected at time 0 (predose) and at 1, 2, 3, 4, 6, and 8 hours postdose; venous cord blood was obtained at delivery. Amoxicillin concentrations were quantified with high-performance liquid chromatography with tandem mass spectrometry. Noncompartmental and population pharmacokinetic analyses were used to summarize parameters and estimate time above MIC (%T > MIC) and time of free drug concentrations >70%MIC (ƒT > 70%MIC), for 500, 750, 875, and 1000 mg dosed every 8 or 12 hours. Results: Participants (n = 13) had a median age of 29 years and gestational age of 31 weeks. Three women (23%) returned for postpartum visits. Amoxicillin concentrations were reduced during pregnancy compared with postpartum: the median 8-hour area under the curve was 14 vs 22.2 mgxh/L ( Conclusions: Oral amoxicillin dosed every 8 hours during pregnancy is needed to maintain concentrations above the syphilis MIC threshold. Modeling suggests that 750 mg every 8 hours maintains adequate exposure during pregnancy and should be evaluated in future trials.
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