ArticleJournal of the ASEAN Federation of Endocrine Societies2026
The Impact of Chronic Kidney Disease on Ulcer-Related Outcomes in Hospitalized Diabetic Foot Ulcers: A Retrospective Study from Thailand.
Article in Journal of the ASEAN Federation of Endocrine Societies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To explore the impact of chronic kidney disease (CKD) on hospitalized patients with diabetic foot ulcers (DFU) at a tertiary diabetes center in Thailand. Methodology: A retrospective study reviewed hospitalized DFU admissions at Vimut-Theptarin Hospital from 2019 to 2023. Ulcer-related outcomes included complete wound healing at 12 months, major and minor amputations, and 1-year mortality. Results: A total of 265 DFU admissions from 225 patients were included (male 60.4%; age, 66.7 ± 13.4 years; A1C, 8.2 ± 2.3%, advanced CKD, 26.1%, peripheral arterial disease, 54.7%). Severe DFU (Wagner grade ≥3) comprised 60.0% of all DFUs and almost one-third of patients had prior amputations. Complete healing occurred in 69.8%; major amputation in 4.9%; minor amputation in 30.9%; and 1-year mortality rate after discharge was 11.7%. Advanced CKD (stages 4-5) increased odds of non-healed ulcers (odds ratio OR, 2.69; 95% confidence interval CI, 1.46-4.98; Conclusion: Advanced chronic kidney disease (CKD) is associated with poorer ulcer-related outcomes in hospitalized patients with diabetic foot ulcers (DFU). Proactive foot care and early referral to multidisciplinary teams, particularly for dialysis-dependent patients, remain essential. Despite ongoing advances in DFU management, these patients continue to face higher rates of non-healing ulcers and mortality, underscoring the need for coordinated inter-institutional care and enhanced public education efforts.
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