Not Only Follicular Helper T-Cells but Also Peripheral Helper T-Cells Expanded Correlate With Disease Severity and B-Cell Differentiation in Graves' Disease.

Zhaowei Huang, Yanfei Jiang, Xinwei Zhang, Xiaorong Yang, Ronghua Song, Jin-An Zhang

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Article in International journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Not Only Follicular Helper T-Cells but Also Peripheral Helper T-Cells Expanded Correlate With Disease Severity and B-Cell Differentiation in Graves' Disease.International journal of endocrinology · 2026
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6 authors.

Zhaowei HuangGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0002-4086-0465

Yanfei JiangGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0002-2753-5254

Xinwei ZhangGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China, shutcm.edu.cn.

Xiaorong YangDepartment of Endocrinology & Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.

Ronghua SongDepartment of Endocrinology & Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China, sumhs.edu.cn.ORCID https://orcid.org/0000-0002-6779-4576

Jin-An ZhangGraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0002-1700-4695

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To study the expression of peripheral helper T (Tph)-cells in the blood and thyroid of Graves' disease (GD) patients and their correlation with B-cells and clinical indicators. Methods: A total of 25 cases of newly diagnosed GD and 25 cases of healthy controls were recruited. Peripheral blood mononuclear cells were isolated. The frequency and proliferative activity of follicular helper T (Tfh)-cells, Tph cells, and B-cells were detected by flow cytometry. Thyroid tissues of 4 patients with GD and 4 normal thyroid tissues were selected for multiple immunofluorescence staining. The number of Tfh cells and Tph cells in the thyroid tissue was observed. Results: Tph and Tfh cells were significantly increased in the blood and thyroid tissue of GD patients compared with healthy controls. Both cells were positively correlated with the proliferative activity of B-cells. The proportion of Tph cells correlated with serum TT4 ( Conclusion: This study demonstrates for the first time that Tph cells are significantly expanded in the blood and thyroid of GD patients. Similar to Tfh cells, Tph cells correlated with GD severity and B-cell differentiation. Therefore, it may be a new target for GD immunotherapy.

Indexed as

B-cellGraves’ diseaselymphoid follicleTfh cellthyroid tissueTph cell

Identifiers

PMID42311494

DOI10.1155/ije/8591694

PMCPMC13270354

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