ArticleHemaSphere2026
Teclistamab in relapsed/refractory light chain amyloidosis: A retrospective multicenter study by the German Society for Amyloid Diseases.
Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
16 authors.
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Abstract
Systemic light chain (AL) amyloidosis is a rare, acquired protein misfolding disorder characterized by extracellular deposition of misfolded immunoglobulin light chain fibrils, resulting in organ damage. Treatment is based on anti-plasma cell regimens derived from multiple myeloma therapy. To date, no approved regimens exist for relapsed/refractory cases. This retrospective multicenter study, performed at 11 centers across Germany, evaluated the efficacy and tolerability of the treatment with teclistamab in 52 patients with relapsed/refractory AL amyloidosis. Hematologic response (≥very good partial response [VGPR]) was achieved in 81% of patients at Day 15, which increased to 95% at 3 months. Flow-minimal residual disease (MRD) was negative in 96% (23/24) of cases. Cardiac and renal responses (≥partial response [PR]) at 6 months were 65% and 78%, respectively. Cytokine release syndrome occurred in 37% of cases, with two classified as Grade 3 and none as Grade 4. Neutropenia Grade 3 or 4 occurred in 5/52 (10%) of patients. The 1-year overall survival was 83%, and the median overall survival was not reached after a median follow-up time of 8.8 months. Factors including difference between involved and non-involved free light chains (dFLC) ≥ 180 mg/L, N-terminal pro-brain natriuretic peptide (NTproBNP) ≥ 8500 pg/mL, glomerular filtration rate (GFR) < 20 mL/min/1.73 m
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