Evidence map›Paper›PMID 42311415›Full record

ArticleFrontiers in pharmacology2026

Larvicidal, oviposition inhibition, electrophysiological, histological, and docking activity of

João Vitor Castro Aguiar, Júlio César Ribeiro de Oliveira Farias de Aguiar, Edna Barbosa de Lima, Ana Carla da Silva, Eduarda Florencio Santos, Paulo Gomes Pereira Júnior, Geanne Karla Novaes Santos, Suyana Karolyne Lino da Rocha, José Jorge Almeida de Andrade, Priscila Soares da Silva and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

João Vitor Castro AguiarChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Júlio César Ribeiro de Oliveira Farias de AguiarChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Edna Barbosa de LimaChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Ana Carla da SilvaChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Eduarda Florencio SantosChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Paulo Gomes Pereira JúniorChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Geanne Karla Novaes SantosChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Suyana Karolyne Lino da RochaChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
José Jorge Almeida de AndradeChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Priscila Soares da SilvaChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Gilson José da Silva Gomes VieiraChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Valéria Wanderley TeixeiraDepartment of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
Glaucilane Dos Santos CruzDepartment of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
Álvaro Aguiar Coelho TeixeiraDepartment of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
Marcílio Martins de MoraesChemistry Department, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
Cláudio Augusto Gomes da CâmaraChemistry Department, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
Paulo Milet-PinheiroEcology Laboratory, Department of Biological Sciences, University of Pernambuco, Petrolina, Pernambuco, Brazil.
André Mesquita MarquesLaboratory of Natural Products Chemistry, National Institute for Pantanal Research, Cuiabá, Mato Grosso, Brazil.
Maria Raquel FigueiredoDepartment of Natural Products, Farmanguinhos/Fiocruz, Rio de Janeiro, Brazil.
Daniela M A F NavarroChemical Ecology Laboratory, Department of Fundamental Chemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Arboviruses represent a serious problem affecting half of the world's population, according to the World Health Organization. Natural products are an option for combating this vector. Method: The essential oil (EO) of Results: Bioassays demonstrated promising larvicidal activity of the essential oil (LC50 = 52.20 ppm) and curzerene (LC50 = 55.70 ppm), as well as a promising oviposition deterrent action, since the oil reduced egg laying by more than 74% at 50 ppm and 65% at 5 ppm, and curzerene reduced egg laying by 65% at 56 ppm. Gas chromatography and electroantennography revealed depolarization of Ae. aegypti antennae by the main constituent of the essential oil (curzerene), which is consistent with the oviposition deterrent activity. Molecular docking studies and histological analyses suggest alterations in the digestive membrane and enzymes during exposure to the essential oil. Conclusion: Therefore, the essential oil of

Indexed as

Aedes aegypticurzereneEugenia unifloralarvicidaloviposition deterrence

Identifiers

PMID42311415
PMCPMC13270230

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.