ArticleFrontiers in pharmacology2026
Decoding neuroimmune ferroptotic vulnerability in isoflurane-induced neonatal neurotoxicity via the SLC7A11/GPX4 axis.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Early-life exposure to general anesthetics has been associated with increased neurodevelopmental vulnerability, but the cell type-resolved mechanisms remain incompletely understood. Here, we investigated whether isoflurane-induced neonatal neurotoxicity is associated with a glia-linked ferroptotic susceptibility state involving altered SLC7A11/GPX4 antioxidant defense signaling. Methods: By integrating single-cell and bulk transcriptomic profiling with Results: Isoflurane exposure was accompanied by neurodevelopmental and behavioral impairments, reduced expression of SLC7A11/GPX4 axis components, increased lipid oxidative damage, and enhanced neuroimmune reactivity, with convergent data suggesting that astrocytes are an important cellular contributor to this injury-associated state. Discussion: Together, these findings support a glia-associated neuroimmune ferroptotic vulnerability framework in isoflurane-induced neonatal neurotoxicity and identify the SLC7A11/GPX4 axis as a candidate mechanism warranting further causal investigation in peri-anesthetic neuroprotection for the developing brain.
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