ArticleFrontiers in aging2026
Physiological amplitude: a systems-level framework for adaptive capacity in aging and metabolism.
Article in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Aging is characterized by progressive loss of physiological complexity, inter-system coordination, and adaptive capacity. While mitochondrial dysfunction, metabolic inflexibility, impaired stress responses, and circadian dysregulation are well established, an integrative systems-level construct linking these processes remains lacking. Objective: To introduce physiological amplitude as a unifying framework describing the bounded dynamic range of coordinated variability across interacting physiological systems. Methods: We develop a conceptual, hypothesis-generating framework grounded in network physiology and systems biology, integrating mitochondrial function, metabolic flexibility, hormetic stress responses, and circadian regulation into a unified architecture of system-level adaptation. Results: Physiological amplitude is defined as the bounded dynamic range within which coordinated multiscale physiological dynamics are maintained. Aging is conceptualized as a progressive contraction of this accessible range across interconnected biological networks. This framework distinguishes physiological amplitude from variability and resilience by positioning it as a higher-order property emerging from constraint-defined interactions across physiological systems. Conclusion: Physiological amplitude provides an integrative framework for interpreting multiscale physiological dynamics and generates testable hypotheses for quantification using continuous monitoring and network-based analysis. As a candidate systems-level descriptor, it may support the development of integrative biomarkers of aging and metabolic decline, pending empirical validation.
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