ArticleFrontiers in physiology2026
Phase-dependent reorganization of circulating miRNA networks following short maximal exercise.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Background: Circulating microRNAs (miRNAs) are proposed biomarkers of exercise-induced stress and adaptation, yet acute responses are heterogeneous across studies. This suggests that miRNA regulation may depend on the temporal phase of the exercise response and on internal physiological stress, rather than on external workload alone. Objective: To characterize phase-specific circulating miRNA responses to short maximal-effort exercise and examine their associations with internal physiological stress, recovery dynamics, and performance. Methods: Eleven healthy young men performed a short maximal-effort cycling bout. Serum miR-103, miR-122, miR-144, and miR-486 were measured before exercise, immediately post-exercise, and 1 h post-exercise. Salivary cortisol and muscle tissue oxygen saturation (StO Results: No uniform exercise-induced change in individual miRNAs was observed. Instead, responses were phase-specific: the acute phase showed coordinated behavior between miR-122 and miR-486 and alignment of molecular responses with exercise-induced tissue deoxygenation (ΔStO Conclusion: Short maximal-effort exercise induces a phase-dependent reorganization of circulating miRNA coordination rather than a single uniform miRNA signature. Circulating miRNA dynamics appear to reflect internal physiological stress and early recovery processes more closely than external workload, supporting a phase-specific, network-based interpretation of miRNA regulation in exercise physiology.
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