ArticleBiomedical optics express2026
Spatially multiplexed random-access Raman probe for in vivo tissue measurements.
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Raman spectroscopy enables label-free identification of biological tissues, but its clinical application remains limited due to low-throughput measurements. Here, we developed a spatially multiplexed random-access Raman probe that enables simultaneous spectral acquisition from arbitrarily selected locations in vivo. Parallel acquisition of up to 1718 spectra in a single exposure has been enabled by using a custom fiber bundle in combination with a spatial light modulator. In vivo measurement of a peripheral nerve in the abdominal cavity of an anesthetized canine demonstrated the feasibility of the developed system for intraoperative tissue identification within 5 s. We further performed discriminant analysis of multipoint spectra from nerve and non-nerve regions in rats, which achieved 92.5% accuracy and sensitivity for nerve discrimination. The developed system provides a basis for efficient and accurate navigation in surgery.
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