ArticleFrontiers in oncology2026
ctDNA-guided precision therapy with trastuzumab deruxtecan plus pyrotinib in HER2-positive breast cancer brain metastases: a case report.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Brain metastases occur in 30-55% of patients with HER2-positive metastatic breast cancer, presenting significant therapeutic challenges. Circulating tumor DNA (ctDNA) monitoring has emerged as a potentially useful tool for earlier molecular detection of disease activity. Case presentation: We report a 35-year-old woman with HER2-positive metastatic breast cancer diagnosed during pregnancy who achieved pathological complete response after standard therapy. Given her young age, Conclusions: This case illustrates the feasibility of incorporating ctDNA monitoring into treatment decisions and provides a hypothesis-generating observation regarding combination therapy in managing HER2-positive brain metastases. The temporal relationship between molecular and radiologic findings observed here suggests potential value for earlier detection of disease activity, although whether such lead time translates into improved clinical outcomes requires prospective validation. The findings support prospective evaluation of this approach, including the ongoing TROPHY trial investigating this therapeutic approach.
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