ArticleFrontiers in oncology2026
Clinicopathological characteristics of alveolar adenoma.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Alveolar adenoma is an uncommon benign lung tumor that typically appears as a well-defined nodule on imaging and pathological examination. Currently, there is limited research on alveolar adenoma. This article aims to present this rare tumor by describing three cases. Methods: We reviewed and analyzed the morphological and immunohistochemical characteristics of three cases using hematoxylin and eosin (HE) staining and immunohistochemistry (IHC). Results: The alveolar adenomas exhibited well-defined tumors composed of well-differentiated cuboidal or flattened alveolar epithelial cells that formed glandular or cystic structures of varying sizes, accompanied by well-differentiated spindle cell stroma. Immunohistochemical analysis showed consistently strong and widespread CD34 expression in the stromal cells in all cases. Additionally, CD10 was diffusely positive in stromal cells in about two-thirds of the cases, with focal positivity observed in the remaining case. Discussion: While previous research has not identified specific immunohistochemical markers, our findings are interesting, and we suggest that these markers could be useful in diagnosing alveolar adenoma.
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