Evidence map›Paper›PMID 42311093›Full record

ReviewHepatic oncology2026

Advances in liver transplantation for hepatic malignancies.

Ingrid Woelfel, Shirley Lowmaster, Mariana Chavez-Villa, Sandra Arias, Channa Jayasekera, Michele Barnhill, Adyr Moss, Amit K Mathur, Nitin N Katariya

Abstract readReview
In one paragraph

Review in Hepatic oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ingrid WoelfelDepartment of Surgery, Division of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, USA.
Shirley LowmasterDepartment of Surgery, Division of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, USA.
Mariana Chavez-VillaDepartment of Surgery, Division of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, USA.
Sandra AriasDepartment of Surgery, Division of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, USA.
Channa JayasekeraDivision of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona, USA.
Michele BarnhillDivision of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona, USA.
Adyr MossDepartment of Surgery, Division of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, USA.
Amit K MathurDepartment of Surgery, Division of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, USA.
Nitin N KatariyaDepartment of Surgery, Division of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transplant Oncology is an evolving field. While liver transplantation was once contraindicated in patients with cancer, the safety and survival benefit of utilizing transplantation as a curative-intent treatment for primary and metastatic hepatic malignancies has been demonstrated. Currently, liver transplantation is offered to selected patients with hepatocellular carcinoma, perihilar and intrahepatic cholangiocarcinoma, colorectal cancer with isolated liver metastases, and neuroendocrine tumors with isolated liver metastases. We will cover the current inclusion and exclusion criteria and clinical and pathologic factors of each oncologic indication, and future directions in liver transplant oncology. Successful oncologic outcomes for liver transplantation hinge on careful selection of patients. The evolving role of immunotherapy and targeted tumor therapies have allowed for previously transplant-ineligible patients to be considered for curative-intent transplantation, rather than palliative-intent care. Increasing our knowledge through coordinated multi-institutional studies of each disease process with liver transplantation will be imperative to continue to safely broaden the indications and offer hope to these complex groups of patients. Reframing recipients with oncologic indications for transplant should occur carefully and with attention to rigorous analysis of clinical outcomes. The objective of this article is to situate the evolving treatments for hepatic malignancies within the expanding scope of transplant oncology.

Indexed as

cholangiocarcinomacolorectal liver metastasishepatocellular carcinomaLiver transplantationtransplant oncology

Identifiers

PMID42311093
PMCPMC13285559

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.