Evidence map›Paper›PMID 42311063›Full record

ArticleACS infectious diseases2026

The Novel Carbapenem, JDB/PQ-1-219, Has Potent Broad Spectrum Activity against Multi-Drug Resistant

Marta Toth, Nichole K Stewart, Ailiena O Maggiolo, Pojun Quan, Md Mahbub Kabir Khan, Jonathan Cox, Maidileyvis Castro Cabello, John D Buynak, Clyde A Smith, Sergei B Vakulenko

Abstract read
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marta TothDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame 46556, Indiana, United States.
Nichole K StewartDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame 46556, Indiana, United States.
Ailiena O MaggioloStanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park 94025, California, United States.
Pojun QuanDepartment of Chemistry, Southern Methodist University, Dallas 75275, Texas, United States.
Md Mahbub Kabir KhanDepartment of Chemistry, Southern Methodist University, Dallas 75275, Texas, United States.
Jonathan CoxDepartment of Chemistry, Southern Methodist University, Dallas 75275, Texas, United States.
Maidileyvis Castro CabelloDepartment of Chemistry, Southern Methodist University, Dallas 75275, Texas, United States.
John D BuynakDepartment of Chemistry, Southern Methodist University, Dallas 75275, Texas, United States.ORCID 0000-0003-1007-791X
Clyde A SmithStanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park 94025, California, United States.ORCID 0000-0002-1885-1511
Sergei B VakulenkoDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame 46556, Indiana, United States.ORCID 0000-0002-5327-8124

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Carbapenemase-Stable Carbapenem Antibiotics for Treatment of Multidrug-Resistant Acinetobacter baumannii InfectionsR01AI155723 · NIAID · UNIVERSITY OF NOTRE DAME · PI BUYNAK, JOHN D, VAKULENKO, SERGEI · 2021 to 2025
$3.9M
Optimization of Atypical Antimycobacterial Carbapenem AntibioticsR01AI174599 · NIAID · SOUTHERN METHODIST UNIVERSITY · PI JOHN D BUYNAK, Konstantin V Korotkov · 2023 to 2026
$2.8M
Antibiotics Designed to Counter Resistant 21st Century PathogensR15AI142699 · NIAID · SOUTHERN METHODIST UNIVERSITY · PI BUYNAK, JOHN D · 2019 to 2019
$437k
NIAID NIH HHS R01 AI155723NIAID NIH HHS R01 AI174599NIAID NIH HHS R15 AI142699NIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

Carbapenem resistance in

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsCarbapenemsDrug Resistance, Multiple, BacterialBacterial Proteinsbeta-LactamasesKineticsMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsAcinetobacter baumanniiantibioticcarbapenemcarbapenemasecrystal structureOXA-23

Identifiers

PMID42311063
PMCPMC13366572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.