Evidence map›Paper›PMID 42310970›Full record

ArticleGut microbes2026

High thrombin activity associated with crohn's disease induces microbiota pathogenicity contributing to mucosal inflammation.

Guillaume Le Cosquer, Melissa Pannier, Julie Thevenin, Laura Guiraud, Melissa David, Alexia Dumas, Elodie Meunier, Perrine Rousset, Simone Palese, Carmine Giorgio and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Guillaume Le CosquerUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Melissa PannierUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Julie TheveninUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Laura GuiraudUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Melissa DavidUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Alexia DumasUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Elodie MeunierUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Perrine RoussetUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Simone PaleseUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Carmine GiorgioUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Louis BuscailUniversité of Toulouse, Toulouse University Hospital (CHU Toulouse), Hôpital Rangueil, Department of Gastroenterology and Pancreatology, Toulouse, France.
Barbara BournetUniversité of Toulouse, Toulouse University Hospital (CHU Toulouse), Hôpital Rangueil, Department of Gastroenterology and Pancreatology, Toulouse, France.
Cyrielle GillettaUniversité of Toulouse, Toulouse University Hospital (CHU Toulouse), Hôpital Rangueil, Department of Gastroenterology and Pancreatology, Toulouse, France.
Adrian CulettoUniversité of Toulouse, Toulouse University Hospital (CHU Toulouse), Hôpital Rangueil, Department of Gastroenterology and Pancreatology, Toulouse, France.
Cindy CanivetUniversité of Toulouse, Toulouse University Hospital (CHU Toulouse), Hôpital Rangueil, Department of Gastroenterology and Pancreatology, Toulouse, France.
Etienne BuscailUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Caroline CamaréUniversité de Toulouse, Toulouse University Hospital (CHU Toulouse), Hôpital Rangueil, Department of Clinical Biochemistry, Toulouse, France.
Laurent AlricUniversité de Toulouse, Toulouse University Hospital (CHU Toulouse), Hôpital Rangueil, Department of Internal Medicine and Clinical Immunology, Toulouse, France.ORCID 0000-0003-0676-7539
Céline DeraisonUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Nathalie VergnolleUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.
Jean-Paul MottaUniversity of Toulouse, INSERM, INRAe, ENVT, Institute of Digestive Health Research (IRSD), Toulouse, France.ORCID 0000-0002-9464-0695

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombin is a serine protease produced by the intestinal epithelium that contributes to mucosal homeostasis by limiting microbial encroachment. In Crohn's disease, mucosal thrombin activity is markedly increased, suggesting a role in disease pathophysiology. We hypothesized that excessive luminal thrombin disrupts host-microbiota interactions and promotes a pathogenic microbial phenotype. Thrombin levels were significantly elevated in fecal samples from a subset of Crohn's disease patients compared with healthy controls.

Indexed as

Crohn DiseaseGastrointestinal MicrobiomeIntestinal MucosaThrombinAdultAnimalsBacteriaBacterial TranslocationBiofilmsColitisDisease Models, AnimalDysbiosisFecesFemaleHumansInflammationThrombinbiofilmsCrohn's diseasedysbiosisfecal biomarkershost–microbiota interactionsmucosal inflammationthrombinToll-Like Receptor 5

Identifiers

PMID42310970
PMCPMC13285544

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.