Evidence map›Paper›PMID 42310936›Full record

ArticleTheScientificWorldJournal2026

In Silico Study of 17-DMAG Derivatives: Integrating QSAR, Molecular Docking, Molecular Dynamics, and ADME Analysis.

Víctor Eljach-Cordoba, Maicol Ahumedo-Monterrosa, Jhoan Piermattey-Ditta, Jairo Mercado-Camargo, Jorge Anaya-Gil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Víctor Eljach-CordobaNatural Products Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena, 130015, Colombia, unicartagena.edu.co.
Maicol Ahumedo-MonterrosaNatural Products Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena, 130015, Colombia, unicartagena.edu.co.
Jhoan Piermattey-DittaNatural Products Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena, 130015, Colombia, unicartagena.edu.co.ORCID https://orcid.org/0009-0008-8206-2331
Jairo Mercado-CamargoNatural Products Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena, 130015, Colombia, unicartagena.edu.co.
Jorge Anaya-GilNatural Products Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena, 130015, Colombia, unicartagena.edu.co.ORCID https://orcid.org/0000-0002-7775-165X

Funding

University of Cartagena
6 · The paper itself

Abstract

The Hsp90 protein is crucial for cancer cell survival by regulating essential processes such as cell division, proteostasis, and the correct folding of proteins, including transcriptional factors, growth factors, and kinases. Due to its therapeutic relevance, Hsp90 has become a target for developing anticancer drugs. In this in silico study, a 2D-QSAR analysis was performed with geldanamycin derivatives, 33 of these selected for the training set, obtaining a model with predictive parameters (R

Indexed as

BenzoquinonesHSP90 Heat-Shock ProteinsLactams, MacrocyclicMolecular Docking SimulationMolecular Dynamics SimulationQuantitative Structure-Activity RelationshipHumansLigandsProtein Binding17-(dimethylaminoethylamino)-17-demethoxygeldanamycinBenzoquinonesgeldanamycinHSP90 Heat-Shock ProteinsLactams, MacrocyclicLigandsADMEgeldanamycinHsp90molecular dynamicsQSAR

Identifiers

PMID42310936
PMCPMC13276006

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.