Evidence map›Paper›PMID 42310856›Full record

ArticleGenesis (New York, N.Y. : 2000)2026

Generation and Characterization of Twist1 Acetyl-Mimic and Acetyl-Deficient Mouse Models.

Mary Elmeniawi, Xiaobin Yu, Samuel Wen, Gunjan A Bhatia, Lan Liao, Jianming Xu, Walid D Fakhouri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genesis (New York, N.Y. : 2000), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mary ElmeniawiDepartment of Diagnostic and Biomedical Sciences, Center for Craniofacial Research, School of Dentistry, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Xiaobin YuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Samuel WenDepartment of Diagnostic and Biomedical Sciences, Center for Craniofacial Research, School of Dentistry, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Gunjan A BhatiaDepartment of Diagnostic and Biomedical Sciences, Center for Craniofacial Research, School of Dentistry, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Lan LiaoDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Jianming XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Walid D FakhouriDepartment of Diagnostic and Biomedical Sciences, Center for Craniofacial Research, School of Dentistry, University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-2199-3828

Funding

Supporting Cancer Research as a Core-based Scientist by Providing Comprehensive Genetically Engineered Rodent Model ServicesR50CA283804 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Lan Liao · 2024 to 2026
$430k
The primary role of low NCOA6 expression in the prostate cancer disparity among African American menR21CA267006 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2022 to 2023
$408k
Gordon Cain Endowed Professorship in Cell BiologyNCI NIH HHS R50 CA283804NIDCR NIH HHS R21CA267006NIH HHS R21CANIH HHS R50CA283804UTHealth President Excellence Accelerator Program 0017324
6 · The paper itself

Abstract

TWIST1 encodes a highly conserved basic helix-loop-helix transcription factor essential for embryonic development from Drosophila to humans. TWIST1 activity is regulated by post-translational modifications, including phosphorylation during development and cancer metastasis. Recent cancer studies identified acetylation of lysines K73 and K76 as a novel regulatory modification that shifts TWIST1 from a repressive to an activating state during epithelial-to-mesenchymal transition (EMT). However, the developmental and in vivo functions of TWIST1 acetylation remain unknown. To investigate the physiological role, we generated the first acetyl-deficient Twist1

Indexed as

Craniofacial AbnormalitiesNuclear ProteinsTwist-Related Protein 1AcetylationAnimalsEpithelial-Mesenchymal TransitionFemaleMiceMice, Inbred C57BLProtein Processing, Post-TranslationalNuclear ProteinsTwist1 protein, mouseTwist-Related Protein 1

Identifiers

PMID42310856
PMCPMC13276015

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.