Evidence map›Paper›PMID 42310832›Full record

ArticleJournal of the science of food and agriculture2026

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen-induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation.

Po-Yao Tsai, Zi-Han Lin, Guor-Jien Wei, Liang-Yi Wu, Tien-Yuan Wu, Yen-Chen Tung, Ssu-Han Huang, Zheng-Yuan Su

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In one paragraph

Article in Journal of the science of food and agriculture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Po-Yao TsaiDepartment of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.
Zi-Han LinDepartment of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.
Guor-Jien WeiInstitute of Food Safety and Health Risk Assessment, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Liang-Yi WuDepartment of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.
Tien-Yuan WuSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan.
Yen-Chen TungDepartment of Food Science, National Ilan University, Yilan County, Taiwan.
Ssu-Han HuangDepartment of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.
Zheng-Yuan SuDepartment of Bioscience Technology, Chung Yuan Christian University, Taoyuan City, Taiwan.ORCID https://orcid.org/0000-0003-2624-9181

Funding

Ministry of Science and Technology (MOST), Taiwan MOST106-2311-B-033-002-MY3
6 · The paper itself

Abstract

backgroundPreventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits. The present study aimed to examine the hepatoprotective effects of Citrus depressa peel ethanolic extract (CD-EE) and its major compounds, nobiletin (Nob) and tangeretin (Tan), in BALB/c mice suffering from chronic liver injury caused by APAP.

resultsCD-EE [250 and 500 mg kg

conclusionThese results suggest that CD-EE, Nob, and Tan are associated with hepatoprotection against APAP-induced chronic liver injury in mice. The modulation of antioxidant mechanisms and epigenetic regulation potentially contributes to this protection, whereas the restoration of gut microbiota composition may represent an additional pathway. © 2026 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

AcetaminophenAntioxidantsChemical and Drug Induced Liver InjuryCitrusFlavonesGastrointestinal MicrobiomePlant ExtractsAnimalsBacteriaEpigenesis, GeneticFruitHumansLiverMaleMiceMice, Inbred BALB CAcetaminophenAntioxidantsFlavonesNF-E2-Related Factor 2nobiletinPlant ExtractsacetaminophenCitrus depressaepigeneticsgut microbiotalivernobiletinNrf2tangeretin

Identifiers

PMID42310832
PMCPMC13543748

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.