ArticleGenome biology2026
SINTER3D: continuous 3D reconstruction of spatial transcriptomics via implicit neural representations.
Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- SINTER3D: continuous 3D reconstruction of spatial transcriptomics via implicit neural representations.Genome biology · 2026Article
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Authors and funding
12 authors.
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Abstract
Spatial transcriptomics enables gene-expression profiling while preserving spatial context, but three-dimensional reconstruction from discrete tissue sections remains limited by large inter-section gaps and gene-wise independent interpolation. We develop SINTER3D, an implicit neural representation-based framework for joint three-dimensional interpolation of multiple genes. SINTER3D models gene expression as continuous functions of three-dimensional coordinates, enabling virtual section generation, spatial-domain identification, and cell-type deconvolution. Across datasets including adult mouse brain, human dorsolateral prefrontal cortex, developing human heart, Drosophila embryo, and breast cancer tissues, SINTER3D outperforms existing methods and reconstructs biologically meaningful three-dimensional molecular structures.
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Registered trials
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