Evidence map›Paper›PMID 42310786›Full record

ArticleJournal of hematology & oncology2026

BTKi orelabrutinib improved the outcome of newly-diagnosed PCNS-LBCL by alleviating MyD88

Yan Yuan, Bo Dai, Haoshu Zhong, Jiajun Zheng, Zhen Fan, Di Chen, Qian Wang, Hao Wu, Yuan Li, Ping Zhu and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematology & oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Yan Yuan *Department of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Bo Dai *Department of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Haoshu Zhong *Department of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Jiajun Zheng *Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhen FanDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Di ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Qian WangDepartment of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Hao WuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yuan LiDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ping ZhuDepartment of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Tianling DingDepartment of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Shu WangDepartment of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Kunpeng WuDepartment of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Yu ZhangDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhenhua WangDepartment of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Rui FengDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Fengping ZhuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Kang ZhengDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhiyong QinDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Bojie YangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Hong ChenDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiaolei LinInstitute of Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yu YaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Dongxiao ZhuangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. zhuangdx@fudan.edu.cn.
Zhifeng ShiDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. shizhifeng@fudan.edu.cn.
Ying MaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. maoying@fudan.edu.cn.
Tong ChenDepartment of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China. chentong@fudan.edu.cn.

Funding

National Key R&D Program of China 2022YFA1103500National Natural & Science Foundation of China 82330004Science and Technology Innovation Plan of Shanghai Science and Technology Commission 23Y21900300
6 · The paper itself

Abstract

Primary central nervous system large B-cell lymphoma (PCNS-LBCL) exhibits the worst prognosis among all extranodal LBCLs, with the enriched genetic mutations in MyD88

Indexed as

Agammaglobulinaemia Tyrosine KinaseCentral Nervous System NeoplasmsLymphoma, Large B-Cell, DiffuseMyeloid Differentiation Factor 88Protein Kinase InhibitorsProto-Oncogene Proteins c-pim-1AnimalsHumansMicePiperidinesPyridinesXenograft Model Antitumor AssaysAgammaglobulinaemia Tyrosine KinaseBTK protein, humanMyeloid Differentiation Factor 88orelabrutinibPIM1 protein, humanPiperidinesProtein Kinase InhibitorsProto-Oncogene Proteins c-pim-1PyridinesBruton’s tyrosine kinase inhibitorCSF-circulating tumor DNA.MyD88 L265POrelabrutinibPIM1Primary CNS large B-cell lymphoma

Identifiers

PMID42310786
PMCPMC13273950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.