Evidence map›Paper›PMID 42310754›Full record

ArticleJournal of nanobiotechnology2026

Vitamin A-coupled MSCs- derived extracellular vesicles relieve acute liver injury by targeting hepatic stellate cells to deliver REDD1.

Tingjuan Huang, Zixu Li, Xinrui Shi, Xinyu Feng, Linyun Wei, Xiaonan Li, Junjie Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tingjuan Huang *Department of Gastroenterology and Hepatology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Zixu Li *Department of Gastroenterology and Hepatology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Xinrui ShiDepartment of Gastroenterology and Hepatology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Xinyu FengDepartment of Gastroenterology and Hepatology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Linyun WeiDepartment of Gastroenterology and Hepatology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Xiaonan LiDepartment of Gastroenterology and Hepatology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, China. leexiaonan168@163.com.
Junjie RenDepartment of Gastroenterology and Hepatology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, China. renjunjie1120@163.com.

Funding

Central guidance for local scientific and technological development funding projects YDZJSX2025D068China postdoctoral science foundation 2025M782136
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) offer great potential for treating liver injury. However, owing to their intrinsic surface characteristics, bare EVs are non-specifically distributed in the liver tissue after systemic administration, leading to limited therapeutic efficacy. Acute liver injury, often induced by acetaminophen overdose, can progress to life-threatening fibrosis, with hepatic stellate cells (HSCs) recognized as central drivers of this pathological process. While regulated in development and DNA damage response 1 (REDD1) has demonstrated antifibrotic effects by inhibiting HSCs activation, its clinical application has been hindered by challenges in targeted delivery. Utilizing the natural affinity of vitamin A (VA) for retinol binding protein receptors on HSCs, this study addresses the critical need for targeted therapies in acute liver injury by developing a novel delivery system based on VA-conjugated EVs (V-EVs) to transport the therapeutic gene REDD1 specifically to activated HSCs (aHSCs). After loading with REDD1 (V-EV

Indexed as

Chemical and Drug Induced Liver InjuryExtracellular VesiclesHepatic Stellate CellsMesenchymal Stem CellsTranscription FactorsVitamin AAnimalsApoptosisHumansLiverLiver CirrhosisMaleMiceMice, Inbred C57BLDdit4 protein, mouseTranscription FactorsVitamin AExtracellular vesiclesHepatic stellate cellsLiver injuryREDD1Targeted delivery

Identifiers

PMID42310754
PMCPMC13520313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.