Evidence map›Paper›PMID 42310747›Full record

Trial reportJournal of neuroengineering and rehabilitation2026

Beyond microprocessor knees: exploring the potential of fully powered prosthetic legs.

Kyle R Embry, Chandrasekaran Jayaraman, Chen Yang, Shenan Hoppe-Ludwig, Matt McGuire, Jonathan Mendley, Chaithanya K Mummidisetty, Brian E Lawson, Kiana Mohammadian, Jasmine Hunt and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03204513 (Impact of Powered Knee-Ankle Prosthesis Leg on Everyday Community Mobility and Social Interaction), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03204513 naactive not recruitingnot on this map

Impact of Powered Knee-Ankle Prosthesis Leg on Everyday Community Mobility and Social Interaction

TypeinterventionalSponsorShirley Ryan AbilityLabRan2016 to 2026Enrolled15ConditionsTransfemoral AmputeesArmsVanderbilt Powered Knee-Ankle Prosthesis, Microprocessor (MP) Knee Prosthesis
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kyle R Embry *Center for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Chandrasekaran Jayaraman *Center for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Chen YangCenter for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Shenan Hoppe-LudwigCenter for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Matt McGuireCenter for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Jonathan MendleyCenter for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Chaithanya K MummidisettyCenter for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Brian E LawsonLittle Room Innovations, LLC, Ann Arbor, MI, USA.
Kiana MohammadianCenter for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Jasmine HuntCenter for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Apurva ReddyCenter for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA.
Michael GoldfarbDepartment of Mechanical Engineering, Vanderbilt University, Nashville, TN, USA.
Keith E GordonDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
Arun JayaramanCenter for Bionic Medicine, Shirley Ryan AbilityLab, Chicago, IL, USA. ajayaraman@sralab.org.

Funding

U.S. Department of Defense W81XWH-15-2-0041
6 · The paper itself

Abstract

backgroundPowered knee and ankle prostheses generate mechanical energy to replicate biological leg function, yet direct comparisons with more commonly prescribed microprocessor-controlled knee prostheses are limited by methodological variability and small sample sizes.

methodsTwelve adults with transfemoral or knee disarticulation limb loss or difference who regularly used microprocessor knees were enrolled in a crossover study. After device fitting and an average of 10 training sessions with a powered knee and ankle prototype, participants completed a comprehensive battery of biomechanical, physiological, and functional assessments. Tests were repeated using each participant's prescribed prosthesis following a two-month washout period to reduce carryover effects. Paired statistical comparisons were used to evaluate differences across key outcome measures.

resultsParticipants walked slightly slower and exhibited marginally reduced swing time symmetry when using the powered prosthesis. However, there were no significant differences in metabolic energy cost between devices, despite the significant increase in weight of the powered prosthesis. This may suggest that the powered leg provided sufficient assistance to compensate for its added weight, but did not yield improvements in walking speed, gait symmetry, or functional endurance.

conclusionsUse of this powered knee and ankle prosthesis resulted in comparable physiological effort and postural control to microprocessor knees, but did not improve outcomes like walking speed, symmetry, or endurance. Continued development of comparative testing protocols for prototype componentry could represents a critical step in optimizing PKA design and validation for improved clinical outcomes. Trial registration This study is registered at ClinicalTrials.gov (Identifier: NCT03204513; Date: 06/27/2017).

Indexed as

Artificial LimbsKnee ProsthesisMicrocomputersProsthesis DesignAdultAmputeesBiomechanical PhenomenaCross-Over StudiesFemaleGaitHumansMaleMiddle AgedWalking

Identifiers

PMID42310747
PMCPMC13579927

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.