ArticleInternational wound journal2026
Multifunctional Oregano-Derived Plasma Polymer Coatings for Wound Healing Applications: An In Vitro Study.
Article in International wound journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Chronic wounds, exacerbated by infection, aging, diabetes, and oxidative stress, remain a significant challenge in clinical management and impose a substantial burden on healthcare systems. This study presents oregano-derived plasma polymers (OPP) as a multifunctional surface coating for advanced wound healing applications. OPP coatings were fabricated using radiofrequency plasma-enhanced chemical vapour deposition and deposited on glass coverslips. Surface chemistry was characterised by x-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy, and hydrophilicity was assessed by water contact angle measurements. Antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus was evaluated using LIVE/DEAD staining and confocal microscopy. Cytocompatibility, cell adhesion, and morphology were analysed using RAW 264.7 macrophage-like cells, as assessed by MTT assays and immunofluorescent staining for actin and nuclei. The immune response was evaluated by quantifying the cytokines, IL-4 and IL-6 using an enzyme-linked immunosorbent assay. Antioxidant properties were assessed by measuring lipopolysaccharide-induced intracellular reactive oxygen species via fluorescence imaging. The pro-regenerative potential was evaluated using in vitro scratch assays with human foreskin fibroblasts, monitored over 30 h with live-cell imaging. OPP surfaces retained key bioactive chemical groups and exhibited enhanced hydrophilicity. They significantly reduced bacterial viability (P. aeruginosa: ~90%, S. aureus: ~40%, p < 0.01) and supported macrophage adhesion, spreading, and viability. OPP downregulated IL-4 expression without elevating IL-6, suggesting a favourable immunomodulatory profile. OPP coatings inhibited LPS-induced reactive oxygen species production (p < 0.0001), demonstrating antioxidant activity. Scratch assays confirmed significantly accelerated fibroblast migration and wound closure on OPP surfaces (p < 0.05). OPP coatings combine antibacterial, anti-inflammatory, antioxidant, and pro-regenerative properties with excellent cytocompatibility, offering a scalable plant-based platform for advanced wound healing and next-generation nature-inspired biomaterials. This study is the first to demonstrate that oregano-derived plasma polymer coatings possess combined antibacterial, antioxidant, immunomodulatory, and pro-regenerative properties relevant to wound healing applications. Future work will focus on in vivo validation and manufacturability optimisation for clinical translation.
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