Evidence map›Paper›PMID 42310460›Full record

ArticleNature2026

Structure of the pre-initiation complex explains CMGE biogenesis.

Thomas Pühringer, Berta Canal, Giacomo Palm, Agata Butryn, Emma C Couves, Oliver Willhoft, Jacob S Lewis, John F X Diffley, Alessandro Costa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas PühringerMacromolecular Machines Laboratory, Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-9127-9120
Berta CanalChromosome Replication Laboratory, Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-8893-1827
Giacomo PalmMacromolecular Machines Laboratory, Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-1142-6392
Agata ButrynMacromolecular Machines Laboratory, Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-5227-4770
Emma C CouvesMacromolecular Machines Laboratory, Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-1381-7530
Oliver WillhoftMacromolecular Machines Laboratory, Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-2422-1839
Jacob S LewisMacromolecular Machines Laboratory, Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-9945-6133
John F X DiffleyChromosome Replication Laboratory, Francis Crick Institute, London, UK.
Alessandro CostaMacromolecular Machines Laboratory, Francis Crick Institute, London, UK. alessandro.costa@crick.ac.uk.ORCID http://orcid.org/0000-0003-1126-2498

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When cells enter S phase, bidirectional DNA replication is initiated through the kinase-regulated recruitment of three activators (Cdc45, GINS and Pol ε) to a duplex-DNA-loaded double hexamer of minichromosome maintenance (MCM) ATPases. Together, these proteins form two CMGE helicases that establish divergent replication forks as they become separated

Indexed as

Cryoelectron MicroscopyDNA HelicasesDNA ReplicationSaccharomyces cerevisiaeAdenosine TriphosphateCell Cycle ProteinsDNA-Binding ProteinsMinichromosome Maintenance ProteinsModels, MolecularMultiprotein ComplexesSaccharomyces cerevisiae ProteinsAdenosine TriphosphateCell Cycle ProteinsDNA-Binding ProteinsDNA HelicasesMinichromosome Maintenance ProteinsMultiprotein ComplexesSaccharomyces cerevisiae ProteinsSLD2 protein, S cerevisiae

Identifiers

PMID42310460
PMCPMC13421386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.