Evidence map›Paper›PMID 42310446›Full record

ArticleNature2026

Molecular basis of polyadenylated RNA fate determination in the nucleus.

Andrii Bugai, Ulrich Hohmann, Ana Lorenzo, Max Graf, Laura Fin, Jérôme O Rouvière, Laszlo Tirian, Yuhui Dou, Marion Le Rest, Patrik Polák and 6 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Prion-Like Protein LENG8-Mediated Nucleation Drives Stress Granule Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrii Bugai *Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Ulrich Hohmann *Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0003-2124-1439
Ana Lorenzo *Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-0249-4927
Max Graf *Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0009-0001-0756-5173
Laura FinResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.
Jérôme O RouvièreDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-0269-1971
Laszlo TirianInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria.
Yuhui DouDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-4291-4671
Marion Le RestDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0009-0007-8682-6944
Patrik PolákDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Dennis JohnsenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Lis JakobsenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark.
Jens Skorstengaard AndersenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark.ORCID http://orcid.org/0000-0002-6091-140X
Julius BrenneckeInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria. julius.brennecke@imba.oeaw.ac.at.ORCID http://orcid.org/0000-0002-5141-0814
Clemens PlaschkaResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria. clemens.plaschka@imp.ac.at.ORCID http://orcid.org/0000-0002-6020-9514
Torben Heick JensenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. thj@mbg.au.dk.ORCID http://orcid.org/0000-0001-5127-1239

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eukaryotic genomes generate a plethora of polyadenylated (pA

Indexed as

Cell NucleusRNA, MessengerRNA StabilityAnimalsDEAD-box RNA HelicasesExosome Multienzyme Ribonuclease ComplexHumansModels, MolecularRibonucleoproteinsDDX39B protein, humanDEAD-box RNA HelicasesExosome Multienzyme Ribonuclease ComplexRibonucleoproteinsRNA, Messenger

Identifiers

PMID42310446
PMCPMC13391367

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.