Evidence map›Paper›PMID 42310395›Full record

ArticleNature aging2026

Aging disrupts spatiotemporal coordination in the cycling murine ovary.

Tammy C T Lan, Alison Kochersberger, Ruth Raichur, Sophia Szady, Hien Tran, Radiana Simeonova, Ashley Helmuth, Andrew Minagar, Maria José Orozco Fuentes, Vipin Kumar and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tammy C T Lan *The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0824-6796
Alison Kochersberger *Buck Institute for Research on Aging, Novato, CA, USA.
Ruth RaichurThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0005-9107-7357
Sophia SzadyDepartment of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.
Hien TranDepartment of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.
Radiana SimeonovaDepartment of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.
Ashley HelmuthDepartment of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0009-0000-6124-666X
Andrew MinagarDepartment of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.
Maria José Orozco FuentesDepartment of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.
Vipin KumarThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Giovanni MarreroThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1587-3624
Irving BarreraThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sarah MangiameliThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Alex K ShalekThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5670-8778
Pardis C SabetiThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9843-1890
Fei ChenThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2308-3649
David S FischerThe Broad Institute of MIT and Harvard, Cambridge, MA, USA. david.fischer@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-1293-7656
Jennifer L GarrisonBuck Institute for Research on Aging, Novato, CA, USA. drjennifergarrison@gmail.com.
Hattie ChungThe Broad Institute of MIT and Harvard, Cambridge, MA, USA. hattie.chung@yale.edu.ORCID http://orcid.org/0000-0001-8417-5606

Funding

Cellular and Circuit Mechanisms of Neuropeptide SignalingR35GM145305 · NIGMS · BUCK INSTITUTE FOR RESEARCH ON AGING · PI GARRISON, JENNIFER L · 2022 to 2025
$2.0M
Dissecting continuous phenotypic transitions in cellular states with novel quantitative experimental and computational methodsR35GM160070 · NIGMS · YALE UNIVERSITY · PI Hattie Chung · 2025 to 2026
$1.0M
Broad Institute Eric and Wendy Schmidt Center fellowshipNIGMS NIH HHS R35 GM145305NIGMS NIH HHS R35 GM160070
6 · The paper itself

Abstract

Throughout the female reproductive lifespan, the ovary undergoes hundreds of cycles of follicle development, ovulation and tissue regeneration. How aging disrupts the coordination of such precise, multicellular interactions across time and space is not well understood. Using Slide-seq, a near-cellular spatial transcriptomics method, here we profile 22 mouse ovaries across the reproductive cycle and chronological ages, capturing 610,620 spots across 69 spatial profiles. We develop a novel segmentation pipeline to examine the multicellular dynamics of 358 oocytes, 668 follicles and 236 corpora lutea to find that aging impairs the spatial and temporal coordination required for folliculogenesis even before reproductive cycles cease. These disruptions are characterized by altered immune cell dynamics, inflammatory signaling and global tissue disorganization, which impair the cyclic remodeling required for ovarian function. Our findings reveal how multicellular niches orchestrate ovarian function and demonstrate that age-related breakdown in tissue organization precedes the end of fertility.

Indexed as

AgingOvaryAnimalsCorpus LuteumFemaleMiceOocytesOvarian FollicleOvulationSpatial Transcriptomics

Identifiers

PMID42310395
PMCPMC13279277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.