Evidence map›Paper›PMID 42310356›Full record

ArticleScientific reports2026

Metabolomic properties of the fluid from the surgical ligation after breast-conserving therapy and intraoperative radiotherapy.

Agnieszka Gdowicz-Kłosok, Łukasz Boguszewicz, Agnieszka Skorupa, Mateusz Ciszek, Maria Turska-di Amico, Małgorzata Krześniak, Barbara Łasut-Szyszka, Maria Sokól, Jerzy Wydmański

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Agnieszka Gdowicz-Kłosok *Radiotherapy Department, Gliwice Branch, Maria Skłodowska-Curie National Research Institute of Oncology, Ul. Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland. Agnieszka.gdowicz-klosok@gliwice.nio.gov.pl.
Łukasz Boguszewicz *Medical Physics Department, Gliwice Branch, Maria Skłodowska-Curie National Research Institute of Oncology, 44-101, Gliwice, Poland.
Agnieszka SkorupaMedical Physics Department, Gliwice Branch, Maria Skłodowska-Curie National Research Institute of Oncology, 44-101, Gliwice, Poland.
Mateusz CiszekMedical Physics Department, Gliwice Branch, Maria Skłodowska-Curie National Research Institute of Oncology, 44-101, Gliwice, Poland.
Maria Turska-di AmicoII Department of Oncological Surgery, Gliwice Branch, Maria Skłodowska-Curie National Research Institute of Oncology, 44-101, Gliwice, Poland.
Małgorzata KrześniakPreclinical Models Laboratory, Gliwice Branch, Maria Skłodowska-Curie National Research Institute of Oncology, 44-101, Gliwice, Poland.
Barbara Łasut-SzyszkaPreclinical Models Laboratory, Gliwice Branch, Maria Skłodowska-Curie National Research Institute of Oncology, 44-101, Gliwice, Poland.
Maria SokólMedical Physics Department, Gliwice Branch, Maria Skłodowska-Curie National Research Institute of Oncology, 44-101, Gliwice, Poland.
Jerzy WydmańskiRadiotherapy Department, Gliwice Branch, Maria Skłodowska-Curie National Research Institute of Oncology, Ul. Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraoperative radiotherapy with low-energy X-rays (IOXRT) is an increasingly utilized modality during breast conserving therapy (BCT). However, the molecular mechanisms by which it affects the postoperative microenvironment have not yet been fully elucidated. Surgical wound fluid (WF) has been shown to modulate cancer cell behavior; however, its metabolomic composition has not previously been characterized in the context of breast cancer. The objective of this study was to evaluate metabolic alterations in postoperative WF and to determine whether IOXRT induces different metabolic signatures compared to mastectomy (AMP). Postoperative WF was collected from 54 breast cancer patients (38 BCT IOXRT; 16 AMP) at two time points: day 1 (A) and day 5 (B) after surgery. The samples were then analyzed by

Indexed as

Breast NeoplasmsMastectomy, SegmentalMetabolomeMetabolomicsFemaleHumansMagnetic Resonance SpectroscopyBreast cancerBreast‑conserving therapy (BCT)Intraoperative radiotherapy (IOXRT)Metabolic biomarkersMultivariateNMR spectroscopyTumor microenvironmentWound fluid metabolomics

Identifiers

PMID42310356
PMCPMC13542276

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.