Evidence map›Paper›PMID 42310317›Full record

ArticleNature communications2026

Cortical and white matter myelination proceed in concert during early infancy.

Stephanie Zika, Kelly Chang, Altan Orhon, John Kruper, Christina Tyagi, Xiaoqian Yan, Sarah Tung, Kalanit Grill-Spector, Ariel Rokem, Mareike Grotheer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Stephanie ZikaDepartment of Psychology, Philipps-Universität Marburg, Marburg, Germany. szika@mpib-berlin.mpg.de.ORCID 0009-0009-8500-0635
Kelly ChangDepartment of Psychology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5385-2782
Altan OrhonDepartment of Psychology, University of Washington, Seattle, WA, USA.
John KruperDepartment of Psychology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0081-391X
Christina TyagiDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0624-9205
Xiaoqian YanInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.ORCID 0000-0003-4711-7428
Sarah TungDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID 0009-0006-8175-5326
Kalanit Grill-SpectorDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5404-9606
Ariel RokemDepartment of Psychology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0679-1985
Mareike GrotheerDepartment of Psychology, Philipps-Universität Marburg, Marburg, Germany.ORCID 0000-0002-8653-1157

Funding

NIH National Institutes of Health & National Science Foundation MH121868NIH National Institutes of Health & National Science Foundation R01-EB027585NIH National Institutes of Health & National Science Foundation R01-EY033628NIH National Institutes of Health & National Science Foundation R01-EY033835NIH NatioNIH National Institutes of Health & National Science Foundationnal Institutes of Health & National Science Foundation MH121867
6 · The paper itself

Abstract

The infant brain undergoes rapid myelination that is critical for healthy brain function. This development has been characterized for gray and white matter independently, but the link between gray and white matter myelination remains unexplored. To close this knowledge gap, we evaluated two complementary myelin-sensitive imaging metrics: Large-scale (N = 273) T1w/T2w and quantitative (N = 21) R1 data. Automated software was employed to identify 26 white matter bundles and map their cortical terminations, before evaluating T1w/T2w and R1 development shortly after birth. Here we show that for both metrics mean values as well as developmental slopes are correlated across tissues. The synchrony of brain T1w/T2w is impacted by postmenstrual age and prematurity, whereas inter-individual differences in this synchrony predict motor outcomes at 17 - 25 months of age. As T1w/T2w and R1 are associated with myelin content, our results reveal an intricate relationship between gray and white matter myelination.

Indexed as

Cerebral CortexGray MatterMyelin SheathWhite MatterChild, PreschoolFemaleHumansInfantInfant, NewbornMagnetic Resonance ImagingMale

Identifiers

PMID42310317
PMCPMC13276173

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.