Evidence map›Paper›PMID 42310292›Full record

ArticleCell death & disease2026

Impact of BECLIN1 haploinsufficiency on goblet cell function and susceptibility to colitis.

Juliani Juliani, Sharon Tran, Tiffany J Harris, Sarah L Ellis, Aysha H Al-Ani, Yashodha Wijebandara, Komal M Patel, Samuel N Young, Marco Evangelista, David Baloyan and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Juliani JulianiDepartment of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia.
Sharon TranOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Tiffany J HarrisOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Sarah L EllisOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.ORCID http://orcid.org/0000-0002-5772-6051
Aysha H Al-AniWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Yashodha WijebandaraDepartment of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia.
Komal M PatelWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Samuel N YoungWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID http://orcid.org/0009-0001-6543-1851
Marco EvangelistaOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
David BaloyanOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Camilla M ReehorstOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Rebecca NightingaleOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Laura J JenkinsOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.
Peter De CruzDepartment of Gastroenterology, Austin Health, Melbourne, VIC, Australia.
Kinga DuszycInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD, Australia.
Benjamin T KileGarvan Institute of Medical Research, Darlinghurst, NSW, Australia.
Alpha S YapInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD, Australia.
John M MariadasonOlivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia.ORCID http://orcid.org/0000-0001-9123-7684
Britt ChristensenWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
André L SamsonWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0002-0637-2716
James M MurphyWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-0195-3949
Walter D Fairlie *Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia. Doug.Fairlie@onjcri.org.au.ORCID http://orcid.org/0000-0002-2498-1160
Erinna F Lee *Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia. Erinna.Lee@latrobe.edu.au.ORCID http://orcid.org/0000-0003-1255-9808

Funding

Department of Education and Training | Australian Research Council (ARC) DP190102612Department of Health | National Health and Medical Research Council (NHMRC) 1172929, 2034104Department of Health | National Health and Medical Research Council (NHMRC) 2002965, 2011584Department of Health | National Health and Medical Research Council (NHMRC) 2008909Department of Health | National Health and Medical Research Council (NHMRC) 2010704, 1136592U.S. Department of Defense (United States Department of Defense) HT94252310088Victorian Cancer Agency (VCA) MCRF19045
6 · The paper itself

Abstract

BECLIN1 is a central regulator of autophagy and endocytic trafficking essential for epithelial homoeostasis. While complete intestinal epithelial loss of BECLIN1 causes fatal enteritis originating in the small intestine, the consequences of its partial loss in the gut remain unclear. Given that BECLIN1 expression can vary in human disease, we investigated whether reduced BECLIN1 is sufficient to impair gut barrier function. Heterozygous Becn1 deletion (Becn1

Indexed as

Beclin-1ColitisGoblet CellsHaploinsufficiencyAnimalsAutophagyCadherinsDextran SulfateIntestinal Barrier FunctionIntestinal MucosaMiceMice, Inbred C57BLBeclin-1Becn1 protein, mouseCadherinsDextran Sulfate

Identifiers

PMID42310292
PMCPMC13365605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.