Evidence map›Paper›PMID 42310217›Full record

ArticleCommunications biology2026

Whole β-glucan particles modulate BCG-induced macrophage and CD4

Yige Cao, Haoran Qu, Qing Tian, Sujuan Sun, Wenwen Zhang, Dan Fang, Pinru Chen, Chenyu Zhao, Xiao-Lian Zhang, Qin Pan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yige Cao *Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China.
Haoran Qu *Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China.
Qing Tian *Hubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China.
Sujuan SunHubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China.
Wenwen ZhangHubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China.
Dan FangHubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China.
Pinru ChenHubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China.
Chenyu ZhaoHubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China.
Xiao-Lian ZhangHubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China.ORCID http://orcid.org/0000-0002-8283-9381
Qin PanHubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China. panqincn@whu.edu.cn.ORCID http://orcid.org/0000-0002-4210-2852
Fengling LuoHubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China. luofengling@whu.edu.cn.
Min LiuHubei Province Key Laboratory of Allergy and Immunology, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, P. R. China. mliu@whu.edu.cn.ORCID http://orcid.org/0000-0001-7095-1344

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81971904
6 · The paper itself

Abstract

Tuberculosis (TB) remains a major global health burden, and Bacille Calmette-Guérin (BCG) provides inconsistent protection against adult pulmonary disease. Adjuvant strategies to enhance BCG efficacy are urgently needed. Here we show that whole β-glucan particles (WGP) enhance BCG-induced immune responses and improve protection against mycobacterial challenge. In vitro, WGP enhances macrophage functions associated with antigen processing during BCG exposure, including phagocytosis, lysosomal acidification, intracellular degradation, and the upregulation of MHC-II/CD80/CD86. WGP co-exposure partially attenuates the early IL-10 response induced by BCG. Mechanistically, whole β-glucan particles activate the Dectin-1-JAK1-STAT1 pathway, and disruption of this axis reduces MHC-II upregulation and impairs macrophage-supported OT-II CD4

Indexed as

BCG Vaccinebeta-GlucansCD4-Positive T-LymphocytesLectins, C-TypeMacrophagesTuberculosisAnimalsDectin-1FemaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionSTAT1 Transcription FactorBCG Vaccinebeta-GlucansDectin-1Lectins, C-TypeSTAT1 Transcription Factor

Identifiers

PMID42310217
PMCPMC13635213

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.