Evidence map›Paper›PMID 42310171›Full record

ArticleMycopathologia2026

Infection by Different Clades of Candidozyma auris in a Galleria mellonella Model: Determining Virulence Levels.

Gabriel Davi Marena, Alejandro Lopez, Gabriela Corrêa Carvalho, Javier Pemán, Jose Manuel Perez-Royo, Victor Garcia-Bustos, Ángel González, Paula Muñoz Brell, María Dolores Pérez Ruiz, Lara Zaragoza Macian and 5 more

Abstract read
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In one paragraph

Article in Mycopathologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gabriel Davi MarenaHealth Research Institute La Fe, Avenida Fernando Abril Martorell, 106 Torre A 6a Planta, 46026, Valencia, Spain.
Alejandro LopezHealth Research Institute La Fe, Avenida Fernando Abril Martorell, 106 Torre A 6a Planta, 46026, Valencia, Spain.
Gabriela Corrêa CarvalhoDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, 14800-903, Brazil.
Javier PemánHealth Research Institute La Fe, Avenida Fernando Abril Martorell, 106 Torre A 6a Planta, 46026, Valencia, Spain.
Jose Manuel Perez-RoyoHealth Research Institute La Fe, Avenida Fernando Abril Martorell, 106 Torre A 6a Planta, 46026, Valencia, Spain.
Victor Garcia-BustosHealth Research Institute La Fe, Avenida Fernando Abril Martorell, 106 Torre A 6a Planta, 46026, Valencia, Spain.
Ángel GonzálezBasic and Applied Research Group (MICROBA), School of Microbiology, University of Antioquia, Medellín, Colombia. angel.gonzalez@udea.edu.co.ORCID http://orcid.org/0000-0002-7052-7938
Paula Muñoz BrellDepartment of Medical Microbiology, University and Polytechnic La Fe Hospital, Valencia, Spain.
María Dolores Pérez RuizDepartment of Pathological Anatomy, La Fe Hospital, Valencia, Spain.
Lara Zaragoza MacianDepartment of Pathological Anatomy, La Fe Hospital, Valencia, Spain.
Carmen Vicente SaezDepartment of Pathological Anatomy, La Fe Hospital, Valencia, Spain.
Antonia Avalos MansillaDepartment of Pathological Anatomy, La Fe Hospital, Valencia, Spain.
Tais Maria BauabSchool of Pharmaceutical Sciences, Department of Biological Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, 14800-903, Brazil.
Marlus ChorilliDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, 14800-903, Brazil.
Alba Ruiz-GaitánHealth Research Institute La Fe, Avenida Fernando Abril Martorell, 106 Torre A 6a Planta, 46026, Valencia, Spain. albacruiz@gmail.com.

Funding

Fapesp 2021/11120-3Instituto de Salud Carlos III JR21/00061
6 · The paper itself

Abstract

introductionCandidozyma auris (formerly Candida auris) is an emerging yeast that causes bloodstream infections, especially in immunocompromised patients, and presents high resistance and virulence rates. To date, six clades have been established worldwide and the number of outbreaks caused by this microorganism has been increasing every year, causing concern in the medical community. Therefore, this study investigated the heterogeneity among clades of C. auris by evaluating the virulence profile and mechanism of infection using an in vivo model of Galleria mellonella.

methodsG. mellonella was infected with different clades (I, II, III and IV) of C. auris, C. albicans ATCC 5341 and C. parapsilosis ATCC 22019 for virulence and histopathologic evaluation.

resultsAggregative strains of C. auris InP13 (I) and VEN C6 (IV) had a greater rate of melanization and larval mortality among the C. auris isolates, therefore, being the most aggressive strains. C. albicans caused the most melanization among all strains at the highest inoculum concentration (10

conclusionThe aggregative strains were more virulent and had a greater ability to form biofilms and granulomas, showing heterogeneity among the different C. auris clades.

Indexed as

Candida aurisLepidopteraMothsAnimalsBiofilmsCandida albicansCandida parapsilosisDisease Models, AnimalGranulomaHistocytochemistryLarvaSurvival AnalysisVirulenceBiofilmsCandida aurisCandidozyma aurisGalleria mellonellaGranulomasInfectionVirulence

Identifiers

PMID42310171
PMCPMC13275587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.