Evidence map›Paper›PMID 42310012›Full record

ArticleScientific data2026

CalciMAP: High-resolution images showing calbindin- and parvalbumin-expressing neurons across the developing and adult mouse brain.

Ingvild E Bjerke, Olga B Rogulina, Monika I Overdevest, Anna Maria Begkai, Arthur Laja, Sharon C Yates, Heidi Kleven, Ingrid Reiten, Menno P Witter, Trygve B Leergaard

Abstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ingvild E BjerkeNeural Systems Laboratory, Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Oslo, Norway. ingvieb@gmail.com.
Olga B RogulinaNeural Systems Laboratory, Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Oslo, Norway.
Monika I OverdevestNeural Systems Laboratory, Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Oslo, Norway.
Anna Maria BegkaiNeural Systems Laboratory, Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Oslo, Norway.
Arthur LajaKavli Institute for Systems Neuroscience, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Sharon C YatesNeural Systems Laboratory, Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Oslo, Norway.
Heidi KlevenNeural Systems Laboratory, Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Oslo, Norway.
Ingrid ReitenNeural Systems Laboratory, Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Oslo, Norway.
Menno P WitterKavli Institute for Systems Neuroscience, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Trygve B LeergaardNeural Systems Laboratory, Institute of Basic Medical Sciences, Department of Molecular Medicine, University of Oslo, Oslo, Norway. t.b.leergaard@medisin.uio.no.

Funding

Horizon 2020 Framework Programme 785907HORIZON EUROPE Framework Programme 101147319Norges Forskningsråd 197467
6 · The paper itself

Abstract

Calcium-binding proteins are abundant in neurons across the brain, serving as essential regulators of neuronal excitability. Dysfunctional regulation of calcium is implicated in a range of neuropsychiatric and neurodevelopmental disorders. Two highly abundant calcium-binding proteins are calbindin and parvalbumin. Despite their importance in brain development, little is known about when and where neurons expressing calbindin and parvalbumin emerge in different brain regions. Most studies into the development of these neurons or their involvement in atypical brain development are limited to one or a few brain regions, and data from these studies are rarely made available. The scarcity of brain-wide information hampers efforts to understand cellular composition changes occurring in the developing brain. Amending this, we here present a brain-wide histological image collection showing calbindin- and parvalbumin-expressing neurons in the mouse brain across five age groups: postnatal day 9, 14, 21, 35 and adult. All the images have been spatially registered to age-specific brain atlases and are made available for both interactive online viewing and download. This collection provides a comprehensive overview of the development of neurons expressing calcium binding proteins in the mouse brain and is tailored for use in analytical workflows to quantify changes across development.

Indexed as

BrainCalbindinsNeuronsParvalbuminsAnimalsMiceCalbindinsParvalbumins

Identifiers

PMID42310012
PMCPMC13635224

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.