Evidence map›Paper›PMID 42310006›Full record

ArticleNature communications2026

Mitochondrial protein OPA3 sustains cardiac function by regulating calcium handling in male mice.

Na Geng, Taiwei Chen, Hao Li, Shan Lu, Yuehong Wang, Ling Gao, Donald M Bers, Xiyuan Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Na Geng *Department of Cardiology, Renji Hospital, School of Medicine, State Key Laboratory for Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China.
Taiwei Chen *Department of Cardiology, Renji Hospital, School of Medicine, State Key Laboratory for Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China.
Hao Li *Institute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Shan Lu *Nanjing Medical University, School of Pharmacy, Nanjing, China.ORCID 0000-0002-7795-6356
Yuehong WangDepartment of Cardiology, Renji Hospital, School of Medicine, State Key Laboratory for Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China.
Ling GaoInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. gaoleng5@126.com.
Donald M BersDepartment of Pharmacology, University of California-Davis, Davis, CA, USA. dmbers@ucdavis.edu.ORCID 0000-0002-2237-9483
Xiyuan LuDepartment of Cardiology, Renji Hospital, School of Medicine, State Key Laboratory for Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China. luxiyuan@sjtu.edu.cn.

Funding

Molecular examination of mitochondrial calcium controlR01HL132831 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BERS, DONALD M, MOLKENTIN, JEFFERY D · 2016 to 2024
$5.9M
NHLBI NIH HHS R01 HL132831
6 · The paper itself

Abstract

Heart failure (HF) is a growing global health burden characterized by impaired cardiac contractility and progressive remodeling, driven in part by disrupted Ca

Indexed as

CalciumHeart FailureMitochondrial ProteinsAnimalsCalcium-Binding ProteinsCardiomyopathy, DilatedHumansMaleMiceMice, KnockoutMitochondria, HeartMyocytes, CardiacPhospholambanSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesCalciumCalcium-Binding ProteinsMitochondrial ProteinsPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPases

Identifiers

PMID42310006
PMCPMC13434718

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.