ReviewThe Journal of reproduction and development2026
Stromal resistance to placental invasion is a derived trait in ruminants.
Review in The Journal of reproduction and development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Placentation exhibits remarkable diversity among mammals, with reported correlations in cancer malignancy and invasiveness of placenta. Challenging the antagonistic pleiotropy hypothesis, which links evolution of invasive placentation to cancer malignancy, we had proposed the Evolved Levels of Invasability (ELI) framework for species with non-invasive epitheliochorial placentation. ELI posits that maternal stromal fibroblasts in epitheliochorial species evolved resistance to trophoblast invasion, secondarily limiting cancer dissemination in other tissues. Recent experiments with even-toed ungulate endometrial fibroblasts (ESFs) revealed that ESFs from ruminants (bovine and sheep) strongly resist trophoblast invasion, whereas porcine fibroblasts exhibit low resistance to invasion. Ruminants display synepitheliochorial placentation, formation of fetal-maternal hybrid epithelial cells are positioned to be in direct contact with maternal stroma. The ruminant condition, however, is evolutionarily derived from epitheliochorial placentation, as seen in pigs, where the trophoblast does not breach the luminal epithelium at all and the trophoblast is never in contact with the stroma. This experimental finding is consistent with our refined ELI hypothesis positing evolution of stromal resistance to invasion in synepitheliochorial placentation, where maternal stroma and trophoblasts are in direct contact with each other, but less resistance in pigs where the stroma does not directly interact with the trophoblast. The non-assortative sorting of placental types across clades offers opportunities to uncover mechanistic processes governing cellular invasion and tissue homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.