ReviewThe Journal of reproduction and development2026
Reconstitution of germ cell and gonadal development for in vitro gamete production.
Review in The Journal of reproduction and development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germ cell formation involves a unique developmental trajectory in which diploid pluripotent cells are transformed into haploid gametes through a series of tightly regulated processes. This trajectory encompasses fundamental biological events, including extensive epigenetic remodeling, sexual fate determination, and meiotic division. Understanding the molecular and cellular mechanisms governing these processes is a fundamental challenge in reproductive biology and medicine, yet many aspects remain elusive. One long-standing strategy to overcome this limitation has been the establishment of in vitro gametogenesis that recapitulates germ cell development under defined culture conditions. In recent years, advances in stem cell biology have dramatically accelerated the development of such systems, opening new experimental platforms to dissect germ cell development. Beyond their value as research tools, these technologies also hold potential as alternative sources of gametes for animal reproduction and, perhaps, for human applications. In this review, we discuss the historical evolution of in vitro gametogenesis, highlight recent progress in the field, and outline the remaining technical and conceptual challenges.
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Registered trials
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