Evidence map›Paper›PMID 42309596›Full record

ArticleJournal, genetic engineering & biotechnology2026

Rising of antimalarial drug resistance Pfmdr1 N86Y and Pfcrt K76T gene in Ethiopia: a systematic review and meta-analysis.

Temesgen Mitiku Yeshanew, Betelhem Abebe Begashaw, Gemechis Waktole Bayisa, Birhan Getie, Nega Birhane

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In one paragraph

Article in Journal, genetic engineering & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Temesgen Mitiku YeshanewDepartment of Biotechnology, Dambi Dollo University, P.O. Box 260, Dambi Dollo, Ethiopia; Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, P.O. Box 196, Gondar, Ethiopia. Electronic address: temesgen.mitiku@uog.edu.et.
Betelhem Abebe BegashawDepartment of Biotechnology, Dambi Dollo University, P.O. Box 260, Dambi Dollo, Ethiopia; Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
Gemechis Waktole BayisaDepartment of Biotechnology, Dambi Dollo University, P.O. Box 260, Dambi Dollo, Ethiopia.
Birhan GetieDepartment of Medical Biotechnology, Institute of Biotechnology, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
Nega BirhaneDepartment of Medical Biotechnology, Institute of Biotechnology, University of Gondar, P.O. Box 196, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn sub-Saharan Africa, including Ethiopia, malaria continues to pose a significant public health risk. Efforts to control the disease are complicated by emerging resistance to current drugs and concerns about the sustained effectiveness of antimalarial medications. The purpose of this systematic review and meta-analysis is to determine the nationwide prevalence of the Pfcrt K76T and Pfmdr1 N86Y genetic mutations in Ethiopia.

methodsWe queried multiple sources for literature, including the Google Scholar, Cochrane Library, Scopus, Web of Science, and PubMed/MEDLINE databases. Final calculations of overall prevalence were displayed in a forest plot. We subsequently conducted a subgroup analysis to determine any variations or differences among the included studies. Publication bias was assessed visually with funnel plots. The entirety of the statistical evaluation was completed using STATA software (version 16).

resultsAmong the 1,843 initially identified studies, twelve full-text articles met the inclusion criteria and were included in the analysis. The pooled prevalence estimates for Pfcrt K76T and Pfmdr1 N86Y were 75% (CI 62-88) and 24% (CI 7-42), respectively. In a subgroup analysis of studies published between 2021-2025 the pooled prevalence of Pfcrt K76T and Pfmdr1 N86Y was 77% and 14%, respectively. In contrast, studies published from 2006 to 2019 revealed different trends, with a lower pooled prevalence of Pfcrt K76T at 74% and Pfmdr1 N86Y at 29%

conclusionsThis systematic review and meta-analysis demonstrated a significant prevalence of the Pfcrt K76T and Pfmdr1 N86Y gene mutation in Ethiopia. Consequently, there is a pressing need to enhance prevention and control measures and implement new strategies to address this issue.

Indexed as

Drug resistanceEthiopiaMalariaMutationsPfcrtPfmdr1Plasmodium falciparum

Identifiers

PMID42309596
PMCPMC13084396

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