ArticleJournal, genetic engineering & biotechnology2026
Evaluation of phloroglucinol for cytotoxic and anti-inflammatory effects in lung adenocarcinoma cells.
Article in Journal, genetic engineering & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
BACKGROUND AND
objectivePhloroglucinol (PGL) is a polyphenol which is present in marine brown algae and has been reported to exhibit antioxidant and immunomodulatory properties. However, its anticancer potential remains largely unexplored. This research examined the cytotoxic, apoptotic, and anti-inflammatory properties of PGL in A549 cell lines, highlighting its potential for repurposing in cancer treatment. METHODS AND MATERIALS: A549 cells were treated with varying concentrations of PGL for different time intervals. Cell viability was assessed by MTT assay, morphological changes by microscopy, and cell cycle progression and apoptosis by flow cytometry. Nuclear condensation and intracellular ROS generation were analyzed using DAPI and DCF-DA staining. Cell migration was examined using a wound healing assay, and transcriptional changes in pro-inflammatory cytokines were quantified by RT-qPCR.
resultsPGL caused dose- and time-dependent cytotoxicity in A549 cells, and the values of IC
conclusionsPGL induced dose and time-dependent cytotoxicity in A549 cells, with G
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