Evidence map›Paper›PMID 42309217›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026

Immunogenomic landscape of the T cell repertoire after human lung transplantation and its clinical relevance.

Wenyu Jiao, Yufeng Shen, Katherine D Long, Tyla Young, Constanza Bay Muntnich, Adriana Prada Rey, Morcel Khwajazadah, Joshua H Wang, Vineetha Mohan, Kortney Rogers and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Wenyu JiaoDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Yufeng ShenDepartment of Systems Biology, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York, USA.
Katherine D LongDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Tyla YoungDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Constanza Bay MuntnichDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Adriana Prada ReyDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Morcel KhwajazadahDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Joshua H WangDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA; Columbia College, Undergraduate Studies, Columbia University, New York, New York, USA.
Vineetha MohanDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Kortney RogersDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Arnold ValenaDepartment of Nursing, New York-Presbyterian Hospital, New York, New York, USA.
Joseph CostaDepartment of Surgery, Columbia University Irving Medical Center, New York, New York, USA.
Luke BenvenutoDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Joshua SonettDepartment of Surgery, Columbia University Irving Medical Center, New York, New York, USA.
Philippe LemaitreDepartment of Surgery, Columbia University Irving Medical Center, New York, New York, USA.
Frank D'OvidioDepartment of Surgery, Columbia University Irving Medical Center, New York, New York, USA.
Selim ArcasoyDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Jianing FuDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York, USA. Electronic address: jf2977@cumc.columbia.edu.

Funding

BD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600k
Five-laser Aurora spectral flow cytometerS10OD030282 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CREUSOT, REMI J · 2022 to 2022
$361k
NIH HHS S10 OD020056NIH HHS S10 OD030282
6 · The paper itself

Abstract

Long-term lung transplant survival is limited by rejection and infection, processes governed by T cells, the posttransplant dynamics of which are poorly defined. Using flow cytometry and T cell receptor (TCR) sequencing of serial bronchoalveolar lavage (BAL) and peripheral blood samples, we monitored T cell chimerism, phenotypes, and clonotypic dynamics in a small cohort of lung transplant recipients. We identified alloreactive clones via mixed lymphocyte reaction/TCR sequence pairing and microbial-reactive clones via database matching. We found a recipient-derived tissue-resident memory T cell repertoire progressively established in BAL, stabilized by preexisting, multitissue-shared clones. Clonal graft-blood overlap was significantly mediated by CD8

Indexed as

allograft dysfunctionalloreactive T cellsinfectionlung transplantationrejectionT cell receptor repertoiretissue-resident memory T cells

Identifiers

PMID42309217
PMCPMC13403488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.